Baryogenesis via leptogenesis in SO(10) models

We discuss the baryogenesis via leptogenesis mechanism within the supersymmetric and nonsupersymmetric SO(10) models. We find that the nonsupersymmetric model, endowed with an intermediate scale, is generally favoured, unless some fine tuning occurs in the supersymmetric case.Comment: 9 pages, RevTex, with 1 figur

Neutrino masses and mixings in SO(10)

Assuming a Zee-like matrix for the right-handed neutrino Majorana masses in the see-saw mechanism, one gets maximal mixing for vacuum solar oscillations, a very small value for $U_{e3}$ and an approximate degeneracy for the two lower neutrino masses. The scale of right-handed neutrino Majorana masses is in good agreement with the value expected in a SO(10) model with Pati-Salam SU(4)\ts SU(2)\ts SU(2) intermediate symmetry.Comment: 11 pages, no figures. References adde

Leptogenesis within a generalized quark-lepton symmetry

Quark-lepton symmetry has been shown to be inconsistent with baryogenesis via leptogenesis in natural schemes of the see-saw mechanism. Within the phenomenological approach of textures, we relax this strict symmetry and propose weaker conditions, namely models of the neutrino Dirac mass matrix $M_D$ which have the same hierarchy as the matrix elements of $M_u$. We call this guide-line generalized $hierarchical$ quark-lepton symmetry. We consider in detail particular cases in which the moduli of the matrix elements of $M_D$ are equal to those of $M_u$. Within the phenomenological approach of textures, we try for the heavy Majorana mass matrix diagonal and off-diagonal forms. We find that an ansatz for $M_D$ preserving the hierarchy, together with an off-diagonal model for the heavy Majorana neutrino mass, is consistent with neutrino masses, neutrino mixing and baryogenesis via leptogenesis for an intermediate mass scale $m_R \sim 10^{12}$ GeV. The preservation of the hierarchical structure could come from a possible symmetry scheme.Comment: 12 pages, RevTex4. Title and abstract changed. Revised and enlarged versio

Bounds for the mass of the heaviest right-handed neutrino in SO(10) theories

By relating the Dirac neutrino mass matrix to the mass of the charged fermions and assuming that the product of the masses of the two lightest left-handed neutrinos is of the order of $\Delta m^2_{sol}$, we derive, within a leptogenesis scenario, a range of values for the mass of the heaviest right-handed neutrino, centered around the scale of $B-L$ symmetry breaking in the SO(10) theory with Pati-Salam intermediate symmetry.Comment: 7 pages, RevTex4. Few correction

Efficient and Generalized Decentralized Monitoring of Regular Languages

Part 2: Monitoring and TestingInternational audienceThis paper proposes an efficient and generalized decentralized monitoring algorithm allowing to detect satisfaction or violation of any regular specification by local monitors alone in a system without central observation point. Our algorithm does not assume any form of synchronization between system events and communication of monitors, uses state machines as underlying mechanism for efficiency, and tries to keep the number and size of messages exchanged between monitors to a minimum. We provide a full implementation of the algorithm with an open-source benchmark to evaluate its efficiency in terms of number, size of exchanged messages, and delay induced by communication between monitors. Experimental results demonstrate the effectiveness of our algorithm which outperforms the previous most general one along several (new) monitoring metrics

Convergence of a semi-discretization scheme for the Hamilton--Jacobi equation: a new approach with the adjoint method

We consider a numerical scheme for the one dimensional time dependent Hamilton--Jacobi equation in the periodic setting. This scheme consists in a semi-discretization using monotone approximations of the Hamiltonian in the spacial variable. From classical viscosity solution theory, these schemes are known to converge. In this paper we present a new approach to the study of the rate of convergence of the approximations based on the nonlinear adjoint method recently introduced by L. C. Evans. We estimate the rate of convergence for convex Hamiltonians and recover the O(sqrt{h}) convergence rate in terms of the L^infty norm and O(h) in terms of the L^1 norm, where h is the size of the spacial grid. We discuss also possible generalizations to higher dimensional problems and present several other additional estimates. The special case of quadratic Hamiltonians is considered in detail in the end of the paper

Neutrinoless double beta decay in SO(10) inspired seesaw models

By requiring the lower limit for the lightest right-handed neutrino mass, obtained in the baryogenesis from leptogenesis scenario, and a Dirac neutrino mass matrix similar to the up-quark mass matrix we predict small values for the $\nu_e$ mass and for the matrix element $m_{ee}$ responsible of the neutrinoless double beta decay, $m_{\nu_e}$ around $5\cdot10^{-3}$ eV and $m_{ee}$ smaller than $10^{-3}$ eV, respectively. The allowed range for the mass of the heaviest right-handed neutrino is centered around the value of the scale of B - L breaking in the SO(10) gauge theory with Pati-Salam intermediate symmetry.Comment: 9 pages, RevTex4. Revised, title change

Leptogenesis with SU(5)-inspired mass matrices

In the baryogenesis via leptogenesis framework the baryonic asymmetry depends on lepton mass matrices. In a previous paper we used SO(10)-inspired mass matrices and we found few possibilities to obtain a sufficient level of asymmetry. In the present paper we use SU(5)-inspired mass matrices, which also allow to check the dependence of the baryonic asymmetry on Dirac neutrino masses. In particular, we find that the large mixing matter solution to the solar neutrino problem, which within SO(10) gives too small asymmetry, can now be favoured.Comment: RevTex, 14 pages with 4 figure

MTOR cross-talk in cancer and potential for combination therapy

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-component complexes, mTORC1 and mTORC2, which interact with each other and with several elements of other signaling pathways. In the past few years, many new insights into mTOR function and regulation have been gained and extensive genetic and pharmacological studies in mice have enhanced our understanding of how mTOR dysfunction contributes to several diseases, including cancer. Single-agent mTOR targeting, mostly using rapalogs, has so far met limited clinical success; however, due to the extensive cross-talk between mTOR and other pathways, combined approaches are the most promising avenues to improve clinical efficacy of available therapeutics and overcome drug resistance. This review provides a brief and up-to-date narrative on the regulation of mTOR function, the relative contributions of mTORC1 and mTORC2 complexes to cancer development and progression, and prospects for mTOR inhibition as a therapeutic strategy